[Main Ingredients] Sulfadiazine and Trimethoprim

[Product Efficacy] 

The product efficacy of Sulfadiazine and Trimethoprim Oral Solution is based on the synergistic action of its two active ingredients, which combine to provide broad-spectrum antibacterial activity. Here's a detailed breakdown of its efficacy:

1. Synergistic Action:

• Sulfadiazine: A sulfonamide antibiotic that inhibits bacterial synthesis of folic acid, which is essential for bacterial growth.
• Trimethoprim: Inhibits dihydrofolate reductase, an enzyme involved in folic acid synthesis. This enhances the antibacterial effect of sulfadiazine.

Together, these two compounds block two sequential steps in folic acid synthesis, which increases their combined antibacterial effectiveness and reduces the likelihood of bacterial resistance.

2. Broad-Spectrum Activity:

Sulfadiazine and Trimethoprim Oral Solution is effective against a wide range of Gram-positive and Gram-negative bacteria, including:

• E. coli
• Streptococcus spp.
• Staphylococcus spp.
• Salmonella spp.
• Pasteurella spp.

This makes the combination useful in treating infections such as:

• Respiratory tract infections (e.g., pneumonia)
• Gastrointestinal infections (e.g., enteritis)
• Urinary tract infections
• Soft tissue and skin infections
• Septicemia

3. Applications in Animals:

This combination is commonly used in animals like:

• Cattle, sheep, goats: For treating pneumonia, foot rot, and metritis.
• Pigs: For treating respiratory infections, enteritis, and bacterial septicemia.
• Poultry: For treating coccidiosis and bacterial infections.

4. Reduced Resistance Risk:

The combination of sulfadiazine and trimethoprim reduces the likelihood of bacterial resistance developing, as it targets two different points in the bacterial folic acid pathway.